Science
How we design and select molecules.
XI is our internal discovery process. It helps us prioritise which molecules are worth making and testing. The methods behind it are proprietary and not disclosed.
How a program runs.
Profile definition
Indication, modality, route, selectivity and developability constraints are fixed before any chemistry is committed to.
Design and prioritisation
Our internal XI process narrows a large design space to the small number of molecules worth making. The methods behind it are proprietary and not disclosed.
Laboratory confirmation
Assays and in-vivo work decide what advances. Nothing progresses on a predicted number alone.
Iteration
Laboratory measurements inform the next round of design, so each cycle is better placed than the last.
Standards
How we run our discovery work.
- Fixed protocols
- Work runs under fixed, versioned protocols, so a result can be reproduced exactly as first produced.
- Provenance
- Inputs, parameters and outputs are recorded together, so any number on a slide can be traced back to the run that produced it.
- Predictions stay predictions
- Predicted values are labelled as predicted and are never presented as measured data.
- Laboratory decides
- Our internal work prioritises what to make. Assays and in-vivo work decide what advances.
From process to programs.
The same process supports our cardiometabolic programs, the XI-MTR series for MASH and our peripherally restricted analgesic.
See the pipeline →